oratory tests: platelets, PT, APTT, antithrombin, coagulation aspects, FVIII inhibitor, endogenous thrombin possible, DOAC concentration.PO181|Long term Recurrence of Venous Thromboembolism: A Retrospective Case-control Study G. Turatti; L. Spiezia; M. Marobin; A. Poretto; E. Borella; C. Simion; P. Simioni University of Padua, Padua, Italy Background: Venous thromboembolism, (VTE) such as both deep vein thrombosis (DVT) and pulmonary embolism (PE), is reported to be the third most frequent cardiovascular illness. Persons affectedResults: Recurrence of VTE was observed in two patients, postthrombotic adjustments have been observed in a single patient just after 6 months of anticoagulant therapy, and recurrent VTE was observed 4 to 32 weeks following cessation of treatment in 3 individuals. In 9 sufferers we identified out a false coagulation issue deficiency, a false FVIII inhibitor, Brd Inhibitor web through DOAC remedy, and in three individuals, we discovered DOAC-induced thrombocytopenia. Conclusions: Therapeutic tactics in such conditions are limited. Optimal management of DOAC therapy failure is not clear along with the solutions incorporate the following: dose escalation, switching more than to an944 of|ABSTRACTalternative anticoagulant, adding an antiplatelet agents. In clinical practice, it is important to determine whether remedy failure is on account of drug (DOAC) or underlying illness. It’s important to properly diagnose recurrence of VTE, to distinguish recurrence from the residual thrombosis, and to correctly interpret the laboratory test outcomes.WO M E N ‘ S H E A LTHFIGURE 1 Normalized ETP evolution with time in 3 various ART ESTROGENS AND PROGESTINICS protocols Conclusions: The hypercoagulable state was greater and persistent LPB0044|Prothrombotic Biomarkers in the course of Controlled Ovarian Stimulation for Assisted Reproductive Tactics J. Hugon-Rodin1; A. Casini2; J. B ard2; A. Poncet 2; P. Fontana2; N. Vulliemoz3; I. Streuliafter stimulation inside the ag-hCG and atg-hCG groups groups in comparison with the atg-GnRH group.LPB0141|Platelet Activation and Platelet Indices as Markers forHospital Saint Joseph, Paris, France; University Hospitals of Geneva,Disease Progression in Girls with Breast Cancer Y. Tera1,two; H. Azzam1; N. Abousamra1; M. Zaki3; A. Eltantawy4; M. Awad4; H. Ghoneim1; M. Othman1Geneva, Switzerland; 3University Hospitals of Lausanne, Lausanne, Switzerland Background: Controlled ovarian stimulation (COS) for assisted reproductive strategies (ART) is linked using a hypercoagulable state and an improved threat of venous thrombosis. The effect on the diverse ART protocols on coagulation biomarkers is unknown. Aims: To assess the evolution of coagulation biomarkers throughout and after the ovarian stimulation comparing three different ART protocols. Techniques: Within this observational multicentre cohort study, infertile women undergoing COS for ART in 2017019 had been included. Written informed consent was obtained and also the study was authorized by the ethics committees. Our principal outcome was endogenous thrombin possible (ETP) assessed by calibrated automated thrombinography (COX-2 Modulator Compound making use of five pM of tissue issue). ETP was measured before stimulation (baseline), around the day of ovulation triggering (triggering) and seven days after triggering. Three protocols were prescribed based on the standards applied: agonist protocol with hCG trigger (ag-hCG); antagonist protocol with hCG trigger (atg-hCG) or GnRH agonist trigger (atgGnRH); evolution of ETP was estimated and compared among groups utilizing mixed effects lin
