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Zhang et al. Parasites Vectors (2015)eight:37 DOI 10.1186/s13071-015-0650-RESEARCHOpen AccessAn association of Aquaporin-4 using the immunoregulation of liver pathology in mice infected with Schistosoma japonicumWeiwei Zhang1, Jifeng Zhu1, Xian Song1, Zhipeng Xu1, Xue Xue2, Xiaojun Chen1, Xiaowei Yang1, Yong Li1, Xiaoxiao Dong1, Sha Zhou1, Wei Li1, Yingying Qian3, Feng Liu1 and Chuan Su1*AbstractBackground: Schistosomiasis is actually a chronic parasitic illness that affects about 200 million men and women. In Schistosomiasis japonica and mansoni, parasite eggs had been trapped in host liver and stimulated the CD4+T cell responses to regulate the formation from the granulomas. Subsequently, excessive granulomatous response in some heavily, and/or repeatedly infected people could lead to chronic liver fibrosis and circulatory impairment. As a result, elucidation on the mechanisms of these responses will not only provide more info to improved understand the mechanisms from the immunoregulation in schistosomiasis, but additionally help to design new therapies to control granuloma-associated immunopathology. The role of aquaporin-4 (AQP4) in water transport has been extensively investigated in the central nervous system (CNS). Lately, studies have show.
