Nstius and coauthors18 (Table 2). They assessed two a lot of insulin aspart
Nstius and coauthors18 (Table two). They assessed two a lot of insulin CCR4 Storage & Stability aspart of distinct age stored as much as 7 days at 37 2 in reservoirs and exposed to constant every day mechanical agitation (30 3 oscillations/min, 2 0.5 cm amplitude displacement).18 Below CSII circumstances, insulin aspart maintained its potency (99 ), and no substantial variations in pH, transformation solutions, or preservatives were observed right after 7 days, compared with reference values. Furthermore, the options were fibril- and precipitate-free. The authors concluded that stability was maintained irrespective of the age on the batch (freshly manufactured versus finish of shelf life). Utilizing identical conditions (37 two ; 30 oscillations/min, two cm amplitude), one more study compared the stability of insulin aspart with insulin glulisine at distinct flow rates (0.3 and 0.9 U/h) over 10 days.19 Test samplesStability and Temperature-Sensitivity of Insulin Analogs–In Vitro FindingsJ Diabetes Sci Technol Vol 7, Problem six, Novemberjdst.orgJ Diabetes Sci Technol Vol 7, Issue 6, NovemberStability and Efficiency of Rapid-Acting Insulin Analogs Used for Continuous Subcutaneous Insulin Infusion: A Systematic ReviewTable 2. Stability of Rapid-Acting Insulin Analogs Exposed to High Temperature and Mechanical Agitation in CSII In Vitro StudiesaStudy (first author) Lougheed16 RAI ILis Length (days) 2 Temp ( ) 37 Agitation (oscillations/min) Stationary Basal/bolus infusion rate 0.five U/h 6 U/bolus 0.eight U/h six U/bolus 0.1 U/h No boli 0.3 U/h No boli 0.9 U/h No boli Device MiniMed 504 HTRON V100 MiniMed 507c HTRONplus DTRON CSII MiniMed 508 MiniMed 508 MiniMed 508 MiniMed 508 MiniMed 508 Solo MicroPump 6 37 35 0.6 U/h 5 U/bolus Solo MicroPump Solo MicroPump Solo MicroPump 6 37 35 0.3 U/h two.5 U/bolus Solo MicroPump Solo MicroPump 14 37 100 0.eight U/h six U/bolus LTB4 Purity & Documentation Purity ( ) Deamidation/ isomerization Manage Lougheed16 ILis 0.58 0.eSamples analyzed R, P R, P R, P R, P R, P R R, P R, P R, P R, P R, P R, P R, P R, P R, P R, P R, PHMWP ( ) Handle 0.20 0.23 0.two 0.2 0.three 0.1 0.20d 0.30d 0.dPotency ( )bObserved 0.26 (R) 0.26 (R) 0.3 (P) 0.three (P) 0.5 (P) 0.1 (R) 0.40 (P) 0.80 (P) 0.30 (P) 0.60 (P)Manage 100.1 102.3 9505 9505 9505 99.2 ND ND ND ND 100d 100d 100d 100d 100d 100d 9505dObservedb 103.6 (P) 103.9 (P) 95.005 (P) 95.005 (P) 95.005 (P) 99.2 (R) ND ND ND ND 9505 (P and R) 9505 (P and R) 9505 (P and R) 9505 (P and R) 9505 (P and R) 9505 (P and R) 9505 (P) pH Handle 7.0.8 7.0.eight Observedb 7.0.eight (P) 7.0.eight (P) ContinuedDeFelippisILiscSenstiusIAsp IAsp73730SenstiusIGlu IAsp IGlu IAsp IGlu ILis0.30d 0.1.2d 0.four.5d 0.1.2d 0.1.2d 0.5.6d 0.1.2d 0.4d0.3.four (P) 0.two.three (R) 0.8.9 (P) 0.8.9 (R) 0.three.four (P) 0.two.three (R) 0.2.3 (P) 0.two.three (R) 1.0.1 (P) 1.0.1 (R) 0.1.2 (P) 0.2.3 (R) 0.three.6 (P)1600 Senesh20 Sharrowjdst.orgIAsp IGlu ILis ILisMiniMed ParadigmPreservative content (mg/ml) Related substances m-cresol Handle 3.15f,g 3.f,gPhenol Manage NA NA Observedb NA NAObservedb 0.59 (P) 0.52 (P)Manage ND NDObservedb ND NDObservedb two.83 (R) 3.05 (R)hKerrJ Diabetes Sci Technol Vol 7, Challenge 6, NovemberStability and Functionality of Rapid-Acting Insulin Analogs Applied for Continuous Subcutaneous Insulin Infusion: A Systematic ReviewTable two. ContinuedPurity ( ) Deamidation/ isomerization e Manage 0.1.four DeFelippis15 ILis 0.1.four 0.1.4 Senstius18 IAsp IAsp Senstius19 IGlu IAsp IGlu 1.two ND ND ND ND 1.1.3d ND 0.25d ND ND 0.25 NDdPreservative content material (mg/ml) Associated substances m-cresol Manage 3.15g 3.15g three.15g 1.72g 1.8d three.dPhenol Control N.
