Name :
GPX4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
GPX4 Rabbit Polyclonal antibody. Positive IP detected in mouse kidney tissue. Positive WB detected in mouse kidney tissue, human testis tissue, mouse testis tissue. Positive IHC detected in human kidney tissue, human testis tissue. Observed molecular weight by Western-blot: 20kd-23kd
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
Glutathione peroxidase 4 antibody; GPx 4 antibody; GPX4 antibody; GSHPx 4 antibody; MCSP antibody; PHGPx antibody; snGPx antibody; snPHGPx antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of GPX4 recombinant protein (Accession Number: NM_002085). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200
Background :
GPX4 (Phospholipid hydroperoxide glutathione peroxidase, mitochondrial) protects cells against membrane lipid peroxidation and cell death. Required for normal sperm development and male fertility.It has two isforms about 20KDa and 22KDa, respectively. GPX4 is a monomer,but it has a tendency to form higher mass oligomers(PMID:17630701).It presents primarily in testis.
References :
Chen X, Xu W, Miao M. Alteration of sperm protein profile induced by cigarette smoking. Acta biochimica et biophysica Sinica. 47(7):504-15. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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