Name :
HBP1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HBP1 Rabbit Polyclonal antibody. Positive WB detected in human brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 58 kDa
Tested applications :
ELISA, WB, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
FLJ16340 antibody; HBP1 antibody; HMG box containing protein 1 antibody; HMG box transcription factor 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HBP1 recombinant protein (Accession Number: XM_017011967). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000
Background :
HMG-box protein 1 (HBP1) is a transcriptional repressor, and has a role in cell cycle progression and tumor suppression. Also it’s a repressor of the cyclin D1 gene and inhibits the Wnt signaling pathway. Interaction with RB1 enhances it’s binding to the H1F0 promoter . Disrupts the interaction between DNA and TCF4. This is a rabbit polyclonal antibody raised against part of C-terminus of HBP1 of human origin.
References :
Pan K, Chen Y, Roth M. HBP1-mediated transcriptional regulation of DNA methyltransferase 1 and its impact on cell senescence. Molecular and cellular biology. 33(5):887-903. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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