Name :
HBS1L antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HBS1L Rabbit Polyclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in Jurkat cells, A2780 cells, mouse brain tissue. Positive IP detected in mouse brain tissue. Observed molecular weight by Western-blot: 75 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
DKFZp686L13262 antibody; EF 1a antibody; ERFS antibody; HBS1 antibody; HBS1 like (S. cerevisiae) antibody; HBS1 like protein antibody; HBS1L antibody; HSPC276 antibody; KIAA1038 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HBS1L recombinant protein (Accession Number: NM_006620). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
HBS1L (HBS1-like), also known as EF-1a or ERFS, is a 684 amino acid protein that belongs to the GTP-binding elongation factor family and exists as multiple alternatively spliced isoforms. Expressed in kidney, brain, heart, placenta, liver, muscle and pancreas, HSB1L is thought to play a role in controlling fetal hemoglobin levels, specifically influencing platelet, monocyte and erythrocyte hemoglobin content. The gene encoding HBS1L maps to a locus on human chromosome 6 that is associated with sickle cell anemia and beta-thalassemia, suggesting a role for HBS1L in the pathogenesis of blood disorders.This antibody specifically recognizes the 75kd human HBS1L protein.
References :
Slevin MK, Meaux S, Welch JD. Deep sequencing shows multiple oligouridylations are required for 3′ to 5′ degradation of histone mRNAs on polyribosomes. Molecular cell. 53(6):1020-30. 2014. Knight JR, Bastide A, Roobol A. Eukaryotic elongation factor 2 kinase regulates the cold stress response by slowing translation elongation. The Biochemical journal. 465(2):227-38. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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