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Name :
HBXIP antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HBXIP Rabbit Polyclonal antibody. Positive FC detected in MCF-7 cells. Positive IHC detected in human hepat℃irrhosis tissue, human breast cancer tissue, human heart tissue, human liver cancer tissue. Positive WB detected in Transfected HEK-293 cells. Observed molecular weight by Western-blot: 22 kDa

Tested applications :
ELISA, WB, IHC, FC

Species reactivity :
Human, Mouse, Rat; other species not tested.

Alternative names :
HBV X interacting protein antibody; HBX interacting protein antibody; HBXIP antibody; XIP antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of HBXIP recombinant protein (Accession Number: NM_006402). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200

Background :
HBXIP, also named as XIP, belongs to the HBXIP family. It is originally identified by its interaction with the C-terminus of hepatitis B virus (HBV) X protein (HBx). HBXIP is a regulator of centrosome dynamics and cytokinesis. HBXIP is able to up-regulate S100A4 though activating STAT4 and inducing DNA methylation of PTEN. HBXIP is a cellular 18kd protein and cytoplasm stain.

References :
Xu F, You X, Liu F. The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. Cancer letters. 333(1):124-32. 2013. Liu S, Li L, Zhang Y. The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells. The Journal of biological chemistry. 287(36):30228-39. 2012.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel