Name :
HBXIP antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HBXIP Rabbit Polyclonal antibody. Positive FC detected in MCF-7 cells. Positive IHC detected in human hepat℃irrhosis tissue, human breast cancer tissue, human heart tissue, human liver cancer tissue. Positive WB detected in Transfected HEK-293 cells. Observed molecular weight by Western-blot: 22 kDa
Tested applications :
ELISA, WB, IHC, FC
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
HBV X interacting protein antibody; HBX interacting protein antibody; HBXIP antibody; XIP antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HBXIP recombinant protein (Accession Number: NM_006402). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
HBXIP, also named as XIP, belongs to the HBXIP family. It is originally identified by its interaction with the C-terminus of hepatitis B virus (HBV) X protein (HBx). HBXIP is a regulator of centrosome dynamics and cytokinesis. HBXIP is able to up-regulate S100A4 though activating STAT4 and inducing DNA methylation of PTEN. HBXIP is a cellular 18kd protein and cytoplasm stain.
References :
Xu F, You X, Liu F. The oncoprotein HBXIP up-regulates Skp2 via activating transcription factor E2F1 to promote proliferation of breast cancer cells. Cancer letters. 333(1):124-32. 2013. Liu S, Li L, Zhang Y. The oncoprotein HBXIP uses two pathways to up-regulate S100A4 in promotion of growth and migration of breast cancer cells. The Journal of biological chemistry. 287(36):30228-39. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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