Name :
HDAC3-specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HDAC3-specific Rabbit Polyclonal antibody. Positive WB detected in HL-60 cells, human stomach tissue, U-937 cells. Observed molecular weight by Western-blot: 50kd
Tested applications :
ELISA, WB
Species reactivity :
human, mouse, rat; other species not tested.
Alternative names :
HDAC3 antibody; histone deacetylase 3 antibody; RPD3 antibody; RPD3 2 antibody; HD3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_003883). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000
Background :
Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. Histone deacetylase (HDAC) and histone acetyltransferase (HAT) are enzymes that regulate transcription by selectively deacetylating or acetylating the (-amino groups of lysines located near the amino termini of core histone proteins. At least 4 classes of HDAC were identified. HDAC3 is a class I HDAC. HDAC3 has histone deacetylase activity and may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. HDAC3 can also down-regulate p53 function and thus modulate cell growth and apoptosis. The gene encoding HDAC3 is regarded as a potential tumor suppressor gene. This antibody is a rabbit polyclonal antibody raised against a peptide mapping within human HDAC3. This antibody is specific to HDAC3, and will not cross react with other HDACs.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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