Name :
HLA class I (HLA-A) antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HLA class I (HLA-A) Mouse Monoclonal antibody. Positive WB detected in Hepg2 cells, HeLa cells, Raji cells, U-937 cells. Positive IHC detected in human tonsillitis tissue, human heart tissue, human spleen tissue. Positive FC detected in HepG2 cells, HEK-293 cells. Observed molecular weight by Western-blot: 44 kDa
Tested applications :
ELISA, WB, FC, IHC
Species reactivity :
Human, Mouse, Rat, Pig; other species not tested.
Alternative names :
HLA A antibody; HLA class I antibody; HLA class I (HLA-A) antibody; HLAA antibody; HLA-A antibody; MHC class I antigen A*3 antibody
Immunogen :
Isotype :
Mouse IgG2b
Preparation :
This antibody was obtained by immunization of HLA class I (HLA-A) recombinant protein (Accession Number: NM_001242758). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200
Background :
Human major histocompatibility complex (MHC) antigens, also referred to as human leukocyte antigens (HLA), are encoded by genes located on the short arm of chromosome 6 (6p21.3). There are two classes of HLA antigens: class I (HLA-A, B and C) and class II (HLA-D). This class I molecules are polymorphic membrane glycoproteins composed of a heavy (alpha) chain (44 kDa) which is encoded by a HLA class I gene (HLA-A, B or C), and β2-microglobulin light (beta) chain (12 kDa). They are involved in the presentation of foreign antigens to the immune system. (PMID: 667938; 3375250)
References :
Zhao X, Sun Q, Tian H, Cong B, Jiang X, Peng C. Loss of heterozygosity at 6p21 and HLA class I expression in esophageal squamous cell carcinomas in China. Asian Pacific journal of cancer prevention : APJCP. 12(10):2741-5. 2011.
Related websites: https://www.medchemexpress.com/antibodies.html
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