Name :
HOP2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HOP2 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, Jurkat cells. Positive IP detected in Jurkat cells. Positive IHC detected in human lung cancer tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 24 kDa and 29 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human; other species not tested.
Alternative names :
GT198 antibody; HOP2 antibody; HUMGT198A antibody; PSMC3 interacting protein antibody; PSMC3IP antibody; TBP 1 interacting protein antibody; TBPIP antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HOP2 recombinant protein (Accession Number: NM_013290). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
PSMC3IP, also called HOP2, encodes a protein that functions in meiotic recombination. It is a subunit of the PSMC3IP/MND1 complex, which interacts with PSMC3/TBP1 to stimulate DMC1- and RAD51-mediated strand exchange during meiosis. The protein encoded by this gene can also co-activate ligand-driven transcription mediated by estrogen, androgen, glucocorticoid, progesterone, and thyroid nuclear receptors. Mutations in this gene cause XX female gonadal dysgenesis.
References :
Cho NW, Dilley RL, Lampson MA, Greenberg RA. Interchromosomal homology searches drive directional ALT telomere movement and synapsis. Cell. 159(1):108-21. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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