Name :
HSP60 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HSP60 Mouse Monoclonal antibody. Positive WB detected in HeLa cells, HepG2 cells, MCF7 cells. Positive IP detected in mouse liver tissue. Positive FC detected in HeLa cells. Positive IF detected in Hela cells. Positive IHC detected in human ovary tumor tissue, human skin cancer tissue, human spleen tissue, human testis tissue, human tonsil tissue, human tonsillitis tissue. Observed molecular weight by Western-blot: 60 kDa
Tested applications :
ELISA, IF, FC, IP, WB, IHC
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
Heat shOCk protein 60 antibody; HSP 60 antibody; HSP60 antibody; HSP65 antibody; HSPD1 antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of HSP60 recombinant protein (Accession Number: NM_002156). Purification method: Protein A purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:1000-1:10000IHC: 1:20-1:200IF: 1:20-1:200
Background :
HSPD1, also known as HSP60, belongs to the chaperonin family and acts as a chaperone to enhance cell survival under physiological stresses. Hsp60 has been shown to be connected with many aspects of cell functions such as protein folding and assembling of polypeptide chains in mitochondria. Recently it has been reported that HSP60 is associated with apoptosis or inhibition of cancer cell growth. (21822415)
References :
Hu L, Su C, Song X. Tetrachlorobenzoquinone triggers the cleavage of Bid and promotes the cross-talk of extrinsic and intrinsic apoptotic signalings in pheochromocytoma (PC) 12 cells. Neurotoxicology. 49:149-57. 2015. Geng J, Sun X, Wang P. Kinases Mst1 and Mst2 positively regulate phagocytic induction of reactive oxygen species and bactericidal activity. Nature immunology. 16(11):1142-52. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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