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Name :
HSPA2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HSPA2 Mouse Monoclonal antibody. Positive IF detected in HeLa cells. Positive IHC detected in human testis tissue. Positive WB detected in NIH/3T3 cells, HeLa cells, ROS1728 cells. Observed molecular weight by Western-blot: 70 kDa

Tested applications :
ELISA, WB, IF, IHC

Species reactivity :
Human, Rat, Mouse; other species not tested.

Alternative names :
Heat shOCk 70 kDa protein 2 antibody; heat shOCk 70kDa protein 2 antibody; HSP70 2 antibody; HSP70 3 antibody; HSPA2 antibody

Immunogen :
Human HSPA2 Recombinant protein (His tag)

Isotype :
Mouse IgG1

Preparation :
This antibody was obtained by immunization of HSPA2 recombinant protein (Accession Number: NM_021979). Purification method: Protein G purified.

Clonality :
Monoclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:5000-1:50000IHC: 1:20-1:200IF: 1:20-1:200

Background :
Human HSPA2 is a member of the HSPA (HSP70) family of heat-shock proteins, encoded by the gene originally described as testis-specific. Recently, it has been reported that HSPA2 can be also expressed in human somatic tissues in a cell-type specific manner. HSPA2 is a cytosol/nuclear protein able to translocate between cytoplasm and nucleus. HSPA2 is involved in sperm maturity, function and fertility. Aberrant expression of HSPA2 in testes has been connected with male infertility. Recently, HSPA2 has attracted increased interest due to its possible involvement in carcinogenesis of non-testicular tissues. This antibody well recognized the endogenous HSPA4 protein in testis and multiple cell lines. (21373891)

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel