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Name :
HSPG2-Specific antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
HSPG2-Specific Rabbit Polyclonal antibody. Positive WB detected in COLO 320 cells. Observed molecular weight by Western-blot: 469 kDa

Tested applications :
ELISA, WB

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
heparan sulfate proteoglycan 2 antibody; HSPG antibody; HSPG2 antibody; Perlecan antibody; PLC antibody; PRCAN antibody; SJA antibody; SJS antibody; SJS1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_005529). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:1000

Background :
HSPG2, also named as PLC and HSPG, is an integral component of basement membranes. It is responsible for the fixed negative electrostatic charge and is involved in the charge-selective ultrafiltration properties. It serves as an attachment substrate for cells. Defects in HSPG2 are the cause of Schwartz-Jampel syndrome (SJS1). Defects in HSPG2 are the cause of dyssegmental dysplasia Silverman-Handmaker type (DDSH). The antibody is specific to HSPG2.

References :
Huang A, Dong J, Li S. Exosomal transfer of vasorin expressed in hepatocellular carcinoma cells promotes migration of human umbilical vein endothelial cells. International journal of biological sciences. 11(8):961-9. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel