Name :
Anti-BIRC5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit Polyclonal to Human BIRC5
Tested applications :
WB, ELISA, ICC/IF, IF
Species reactivity :
Human Survivin / BIRC5 / API4
Alternative names :
baculoviral IAP repeat containing 5 antibody; BIRC5 antibody; API4 antibody; EPR-1 antibody; apoptosis inhibitor 4 antibody; apoptosis inhibitor survivin antibody; baculoviral IAP repeat-containing protein 5 antibody; survivin variant 3 alpha antibody; baculoviral IAP repeat-containing 5 antibody; Birc5 antibody; RP23-268N22.2 antibody; AAC-11 antibody; Api4 antibody; TIAP antibody; survivin40 antibody; apoptosis inhibitor 4 antibody; apoptosis inhibitor survivin antibody; baculoviral IAP repeat-containing protein 5 antibody; survivin antibody; IAP4 antibody
Immunogen :
Human Survivin/BIRC5/API4 recombinant protein
Isotype :
Rabbit IgG
Preparation :
Produced in rabbits immunized with purified, recombinant Human Survivin / BIRC5 / API4 . Survivin / BIRC5 / API4 specific IgG was purified by Human Survivin / BIRC5 / API4 affinity chromatography.
Clonality :
Polyclonal
Formulation :
0.2 μm filtered solution in PBS
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
WB: 5-20 μg/mlELISA: 0.1-0.2 μg/mlThis antibody can be used at 0.1-0.2 μg/ml with the appropriate secondary reagents to detect Human Survivin / BIRC5 / API4.ICC/IF: 0.5-3 μg/mL
Background :
BIRC5, also known as Survivin and EPR-1, is a member of the IAP family. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but BIRC5 has only a single BIR domain. It is expressed cell cycle-dependently and highly expressed at mitosis. As a multitasking protein, BIRC5 has dual roles in promoting cell proliferation and preventing apoptosis. Survivin is a component of a chromosome passage protein complex (CPC) which is essential for chromosome alignment and segregation during mitosis and cytokinesis. Survivin acts as an important regulator of the localization of this complex. It may counteract a default induction of apoptosis in G2/M phase.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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