Name :
HTRA2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HTRA2 Rabbit Polyclonal antibody. Positive IP detected in Raji cells. Positive WB detected in HEK-293 cells, COS-7 cells, HeLa cells, human heart tissue, Jurkat cells, MCF7 cells, mouse skeletal muscle tissue, Raji cells. Positive IHC detected in human kidney tissue, human colon tissue, human thyroid tissue. Observed molecular weight by Western-blot: 36 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat, Monkey; other species not tested.
Alternative names :
HtrA serine peptidase 2 antibody; HTRA2 antibody; OMI antibody; PARK13 antibody; PRSS25 antibody; Serine protease 25 antibody; Serine proteinase OMI antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HTRA2 recombinant protein (Accession Number: NM_013247). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
HTRA2(High temperature requirement protein A2) is also named as OMI, PRSS25 and belongs to the peptidase S1B family. HTRA2 normally exists in the mitochondria, can cause MMP3 activation in the cytosol under a cell stress condition, which can ultimately lead to demise of dopaminergic neuronal cells(PMID: 22265821). It inhibits mitochondrial superoxide generation, stabilizes mitochondrial membrane potential, and prevents apoptosis at baseline and in response to extracellular inducers of mitochondrial stress(PMID: 18772386). This protein has 4 isoforms produced by alternative splicing.
References :
Behbahani H, Pavlov PF, Wiehager B, Nishimura T, Winblad B, Ankarcrona M. Association of Omi/HtrA2 with γ-secretase in mitochondria. Neurochemistry international. 57(6):668-75. 2010.
Related websites: https://www.medchemexpress.com/antibodies.html
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