Name :
HUS1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
HUS1 Rabbit Polyclonal antibody. Positive WB detected in BxPC-3 cells. Positive IHC detected in human colon cancer tissue. Observed molecular weight by Western-blot: 32 kDa
Tested applications :
ELISA, IHC, WB
Species reactivity :
Human; other species not tested.
Alternative names :
Checkpoint protein HUS1 antibody; hHUS1 antibody; HUS1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of HUS1 recombinant protein (Accession Number: NM_004507). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: N/AIHC: 1:20-1:200
Background :
Hus1 belongs to the Rad family, form a heterotrimeric clamp with Rad1and Rad9 that acts as a putative sensor for DNA damage. This complex plays an apical role in the DNA damage response, loss of a functional complex affects many downstream checkpoint pathways [PMID: 11340080]. It is also a key complex involved in the activation of the ATR pathway. 9-1-1 forms a ring-shaped heterotrimer, resembling the homotrimeric sliding clamp, proliferating cell nuclear antigen (PCNA) [PMID: 19535328].
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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