IA-2/PTPRN antibody | Gardos-Channel-gardos-channel.com

Name :
IA-2/PTPRN antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
IA-2/PTPRN Mouse Monoclonal antibody. Positive IF detected in HepG2 cells. Positive IHC detected in human brain tissue. Positive WB detected in Human brain, human brain tissue. Observed molecular weight by Western-blot: 60 kDa

Tested applications :
ELISA, WB, IF, IHC

Species reactivity :
Human; other species not tested.

Alternative names :
FLJ16131 antibody; IA 2/PTP antibody; IA2 antibody; IA-2 antibody; ICA 512 antibody; ICA3 antibody; ICA512 antibody; Islet cell antigen 512 antibody; Islet cell autoantigen 3 antibody; PTP IA 2 antibody; PTPRN antibody; R PTP N antibody

Immunogen :
Human PTPRN Recombinant protein (His tag)

Isotype :
IgG3

Preparation :
This antibody was obtained by immunization of IA-2/PTPRN recombinant protein (Accession Number: BC007713). Purification method: Protein A purified.

Clonality :
Monoclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100

Background :
IA-2/PTPRN is a member of the protein tyrosine phosphatase (PTP) family, which contains a transmembrane region, an intracellular PTP-like domain and an extracellular N-terminus. Experiments found that IA-2/PTPRN localizes to secretory granules and is exclusively expressed in neuroendocrine cells (including pancreatic islets cell). IA-2/PTPRNwas found to be a major autoantigen in insulin-dependent diabetes mellitus and the detection of autoantibodies against IA-2/PTPRN is commonly used as a diabetes diagnosis marker.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel

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