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Name :
Icam1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Icam1 Rabbit Polyclonal antibody. Positive IHC detected in mouse liver tissue. Positive WB detected in mouse brain tissue. Observed molecular weight by Western-blot: 85-95 kDa

Tested applications :
ELISA, WB, IHC

Species reactivity :
Mouse,Rat; other species not tested.

Alternative names :
CD54 antibody; ICAM 1 antibody; Icam1 antibody; Ly 47 antibody; MALA 2 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Recombinant Protein (Accession Number: NM_010493). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:20-1:200

Background :
ICAM-1 (Intercellular Adhesion Molecule-1, CD54) is a glycosylated, transmembrane protein, a member of Ig super family. This protein involves in cell adhesion by interacting with a number of 2 integrin family members such as LFA-1 and Mac-1. Its expression is regulated by chemokines. This protein migrates approximately 115 kDa on SDS gels.

References :
Roland CL, Dineen SP, Toombs JE. Tumor-derived intercellular adhesion molecule-1 mediates tumor-associated leukocyte infiltration in orthotopic pancreatic xenografts. Experimental biology and medicine (Maywood, N.J.). 235(2):263-70. 2010. Suzuki AM, Yoshimura A, Ozaki Y, Kaneko T, Hara Y. Cyclosporin A and phenytoin modulate inflammatory responses. Journal of dental research. 88(12):1131-6. 2009. Arakawa Y, Shimada M, Utsunomiya T, Imura S, Morine Y, Ikemoto T. Effects of pegylated interferon α2b on metastasis of hepatocellular carcinoma. The Journal of surgical research. 172(1):95-101. 2012. Zhu H, Shao Q, Sun X. Bone marrow cells: Important role on neovascularization of hepatocellular carcinoma. Journal of gastroenterology and hepatology. 27(7):1241-51. 2012. Sun XT, Yuan XW, Zhu HT. Endothelial precursor cells promote angiogenesis in hepatocellular carcinoma. World journal of gastroenterology. 18(35):4925-33. 2012. Garin A, Meyer-Hermann M, Contie M. Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation. Immunity. 33(1):84-95. 2010. Chen G, Zhao J, Yin Y. C-type natriuretic peptide attenuates LPS-induced endothelial activation: involvement of p38, Akt, and NF-κB pathways. Amino acids. 46(12):2653-63. 2014. Wang YS, Li YX, Zhao P. Anti-inflammation Effects of Oxysophoridine on Cerebral Ischemia-Reperfusion Injury in Mice. Inflammation. 38(6):2259-68. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel