Name :
ICT1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ICT1 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive WB detected in A2780 cells, SKOV-3 cells. Positive IP detected in SKOV-3 cells. Observed molecular weight by Western-blot: 19-24kd
Tested applications :
ELISA, WB, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
Digestion substraction 1 antibody; DS 1 antibody; DS1 antibody; ICT1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of ICT1 recombinant protein (Accession Number: NM_001545). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:1000IF: 1:10-1:100
Background :
The adult colon epithelium contains 3 differentiated cell types that arise from a multipotent stem cell. Deviation from the normal maturation pathway by neoplastic transformation is thought to initiate in stem cells or their early descendants. One potential marker is immature colon carcinoma transcript 1 (ICT1, synonym: DS-1) whose mRNA and protein were more highly expressed in undifferentiated than in differentiated cells. This antibody is a rabbit polyclonal antibody raised against a full-length human ICT1 protein
References :
Serre V, Rozanska A, Beinat M. Mutations in mitochondrial ribosomal protein MRPL12 leads to growth retardation, neurological deterioration and mitochondrial translation deficiency. Biochimica et biophysica acta. 1832(8):1304-12. 2013. Dujeancourt L, Richter R, Chrzanowska-Lightowlers ZM, Bonnefoy N, Herbert CJ. Interactions between peptidyl tRNA hydrolase homologs and the ribosomal release factor Mrf1 in S. pombe mitochondria. Mitochondrion. 13(6):871-80. 2013. Dalla Rosa I, Durigon R, Pearce SF. MPV17L2 is required for ribosome assembly in mitochondria. Nucleic acids research. 42(13):8500-15. 2014. Tu YT, Barrientos A. The Human Mitochondrial DEAD-Box Protein DDX28 Resides in RNA Granules and Functions in Mitoribosome Assembly. Cell reports. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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