Name :
ID3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ID3 Rabbit Polyclonal antibody. Positive WB detected in Transfected HEK-293 cells.
Tested applications :
ELISA, WB
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
1R21 antibody; bHLHb25 antibody; HEIR 1 antibody; HEIR1 antibody; ID3 antibody; Inhibitor of DNA binding 3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of ID3 recombinant protein (Accession Number: NM_002167). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
The helix-loop-helix (HLH) family of transcription factors plays a central role in the regulation of cell growth, differentiation and tumourigenesis. Members of the Id (inhibitor of DNA binding) class of these nuclear proteins are able to heterodimerise with and thereby antagonise the functions of other transcription factors of this family. Inhibitor of DNA binding 3, dominant negative helix-loop-helix protein (ID3, synonym: HEIR-1) is a member of the ID family of HLH proteins, which lacks a basic DNA-binding domain and inhibits transcription through formation of nonfunctional dimers that are incapable of binding to DNA.
References :
Woo GH, Takahashi M, Inoue K. Cellular distributions of molecules with altered expression specific to thyroid proliferative lesions developing in a rat thyroid carcinogenesis model. Cancer science. 100(4):617-25. 2009.
Related websites: https://www.medchemexpress.com/antibodies.html
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