Name :
Anti-BLNK Rabbit antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
BLNK Rabbit monoclonal antibody
Tested applications :
WB, IP
Species reactivity :
Human, Mouse, Rat
Alternative names :
bca; AGM4; BASH; LY57; SLP65; BLNK-S; SLP-65 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide of human BLNK
Clonality :
Monoclonal
Formulation :
Supplied in 50nM Tris-Glycine(pH 7.4), 0.15M Nacl, 40%Glycerol, 0.01% sodium azide and 0.05% BSA.
Storage instructions :
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
WB: 1/1000IP: 1/20
Background :
Swiss-Prot Acc.Q8WV28.Functions as a central linker protein, downstream of the B-cell receptor (BCR), bridging the SYK kinase to a multitude of signaling pathways and regulating biological outcomes of B-cell function and development. Plays a role in the activation of ERK/EPHB2, MAP kinase p38 and JNK. Modulates AP1 activation. Important for the activation of NF-kappa-B and NFAT. Plays an important role in BCR-mediated PLCG1 and PLCG2 activation and Ca2+ mobilization and is required for trafficking of the BCR to late endosomes. However, does not seem to be required for pre-BCR-mediated activation of MAP kinase and phosphatidyl-inositol 3 (PI3) kinase signaling. May be required for the RAC1-JNK pathway. Plays a critical role in orchestrating the pro-B cell to pre-B cell transition. May play an important role in BCR-induced B-cell apoptosis.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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