Name :
IER3 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to IER3
Tested applications :
WB, IHC
Species reactivity :
Human, Mouse
Alternative names :
IER3 antibody; DIF-2 antibody; DIF2 antibody; GLY96 antibody; IEX-1 antibody; IEX-1L antibody; IEX1 antibody; PRG1 antibody; immediate early response 3 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide corresponding to a sequence within amino acids 50 to the C-terminus of human IER3 (NP_003888.2).
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000IHC 1:50 – 1:100
Background :
May play a role in the ERK signaling pathway by inhibiting the dephosphorylation of ERK by phosphatase PP2A-PPP2R5C holoenzyme. Acts also as an ERK downstream effector mediating survival. As a member of the NUPR1/RELB/IER3 survival pathway, may provide pancreatic ductal adenocarcinoma with remarkable resistance to cell stress, such as starvation or gemcitabine treatment.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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