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Name :
IFIT2 Polyclonal Antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Polyclonal antibody to IFIT2

Tested applications :
WB

Species reactivity :
Human

Alternative names :
IFIT2 antibody; G10P2 antibody; GARG-39 antibody; IFI-54 antibody; IFI-54K antibody; IFI54 antibody; IFIT-2 antibody; ISG-54 K antibody; ISG-54K antibody; ISG54 antibody; P54 antibody; cig42 antibody; interferon-induced protein with tetratricopeptide repeats 2 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
Antigen: Recombinant fusion protein containing a sequence corresponding to amino acids 273-472 of human IFIT2 (NP_001538.4).

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.

Storage instructions :
Store at -20℃. Avoid freeze / thaw cycles.

Applications :
WB 1:500 – 1:2000

Background :
IFN-induced antiviral protein which inhibits expression of viral messenger RNAs lacking 2′-O-methylation of the 5′ cap. The ribose 2′-O-methylation would provide a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Viruses evolved several ways to evade this restriction system such as encoding their own 2′-O-methylase for their mRNAs or by stealing host cap containing the 2′-O-methylation (cap snatching mechanism). Binds AU-rich viral RNAs, with or without 5′ triphosphorylation, RNA-binding is required for antiviral activity. Can promote apoptosis.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel