Name :
IFITM2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IFITM2 Rabbit Polyclonal antibody. Positive WB detected in MCF-7 cells, human lung tissue. Positive IP detected in HepG2 cells. Positive IHC detected in human breast cancer tissue, human ovary tumor tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 15kd
Tested applications :
ELISA, IP, IHC, IF, WB
Species reactivity :
Human; other species not tested.
Alternative names :
1 8D antibody; IFITM2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IFITM2 recombinant protein (Accession Number: NM_006435). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:200-1:1000IHC: 1:20-1:200IF: 1:20-1:200
Background :
IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus , by inhibiting the early steps of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death. IFITM proteins are recently identified as viral restriction factors that inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. Also they serve as important components of the innate immune system to restrict HIV-1 infection. Catalog#12769-1-AP is a rabbit polyclonal antibody produced with full-length of human IFITM2.
References :
Jiang D, Weidner JM, Qing M. Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections. Journal of virology. 84(16):8332-41. 2010. Tartour K, Appourchaux R, Gaillard J. IFITM proteins are incorporated onto HIV-1 virion particles and negatively imprint their infectivity. Retrovirology. 11:103. 2014. Qian J, Le Duff Y, Wang Y. Primate lentiviruses are differentially inhibited by interferon-induced transmembrane proteins. Virology. 474:10-8. 2015. Compton AA, Bruel T, Porrot F. IFITM proteins incorporated into HIV-1 virions impair viral fusion and spread. Cell host & microbe. 16(6):736-47. 2014. Zhang W, Zhang L, Zan Y, Du N, Yang Y, Tien P. Human respiratory syncytial virus infection is inhibited by IFN-induced transmembrane proteins. The Journal of general virology. 96(Pt 1):170-82. 2015. Rosati A, Basile A, D’Auria R. BAG3 promotes pancreatic ductal adenocarcinoma growth by activating stromal macrophages. Nature communications. 6:8695. 2015. Wrensch F, Winkler M, Pöhlmann S. IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms. Viruses. 6(9):3683-98. 2014. Wrensch F, Karsten CB, Gnirß K. Interferon-Induced Transmembrane Protein-Mediated Inhibition of Host Cell Entry of Ebolaviruses. The Journal of infectious diseases. 212 Suppl 2:S210-8. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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