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Name :
IFITM2-specific antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
IFITM2-specific Mouse Monoclonal antibody. Positive FC detected in HeLa cells. Positive WB detected in HepG2 cells, MCF7 cells, recombinant protein. Observed molecular weight by Western-blot: 15 kDa

Tested applications :
ELISA, WB, FC

Species reactivity :
Human; other species not tested.

Alternative names :
DSPA2c antibody; IFITM2 antibody

Immunogen :

Isotype :
Mouse IgG1

Preparation :
This antibody was obtained by immunization of recombinant protein (Accession Number: NM_006435). Purification method: Protein G purified.

Clonality :
Monoclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000

Background :
IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death.(PMID:19544527) This antibody is specific to IFTIM2.

References :
Zhu X, He Z, Yuan J. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cellular microbiology. 17(1):105-18. 2015.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel