Name :
IFITM2-specific antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IFITM2-specific Mouse Monoclonal antibody. Positive FC detected in HeLa cells. Positive WB detected in HepG2 cells, MCF7 cells, recombinant protein. Observed molecular weight by Western-blot: 15 kDa
Tested applications :
ELISA, WB, FC
Species reactivity :
Human; other species not tested.
Alternative names :
DSPA2c antibody; IFITM2 antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of recombinant protein (Accession Number: NM_006435). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
IFITM2, also named as 1-8D, belongs to the CD225 family. It is an IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus (WNV), by inhibiting the early step(s) of replication. IFITM2 induces cell cycle arrest and mediates apoptosis by caspase activation and in p53-independent manner. It is overexpressed in colon carcinoma. IFITM2 is a novel pro-apoptotic gene that will provide new insights into the regulated cellular pathways to death.(PMID:19544527) This antibody is specific to IFTIM2.
References :
Zhu X, He Z, Yuan J. IFITM3-containing exosome as a novel mediator for anti-viral response in dengue virus infection. Cellular microbiology. 17(1):105-18. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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