Name :
IFITM3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IFITM3 Mouse Monoclonal antibody. Positive WB detected in Hela cells, human placenta tissue. Positive FC detected in HeLa cells. Positive IHC detected in human lung cancer tissue. Positive IF detected in HepG2 cells. Observed molecular weight by Western-blot: 14 kDa
Tested applications :
ELISA, WB, IF, IHC, FC
Species reactivity :
Human; other species not tested.
Alternative names :
1 8U antibody; IFITM3 antibody; IP15 antibody
Immunogen :
Isotype :
Mouse IgG1
Preparation :
This antibody was obtained by immunization of IFITM3 recombinant protein (Accession Number: NM_021034). Purification method: Protein G purified.
Clonality :
Monoclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
IFITM3, also named as interferon-inducible protein 1-8U, belongs to the CD225 family. It is IFN-induced antiviral protein that mediates cellular innate immunity to at least three major human pathogens, namely influenza A H1N1 virus, West Nile virus (WNV), and dengue virus, by inhibiting the early steps of replication. IFITM3 is identified as interferon-induced cellular proteins that restrict infections by retroviruses and filoviruses and of influenza virus and flaviviruses, respectively. IFITM3, the most potent antiviral IFITM, was found to inhibit an uncharacterized early infectious event after VSV endocytosis, but before primary transcription of its viral genome. IFITM proteins are viral restriction factors that can inhibit infection mediated by the influenza A virus (IAV) hemagglutinin (HA) protein. They differentially restrict the entry of a broad range of enveloped viruses, and modulate cellular tropism independently of viral receptor expression. This antibody recognizes both IFITM2 and IFITM3.
References :
Xie M, Xuan B, Shan J. Human cytomegalovirus exploits interferon-induced transmembrane proteins to facilitate morphogenesis of the virion assembly compartment. Journal of virology. 89(6):3049-61. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Ozoralizumab
VDAC1 Antibody
HA tag Antibody (YA856): Anti-HA tag Antibody is a non-conjugated and Rabbit origined monoclonal antibody. It can be used for WB,IP assays in the background of .
