Name :
IFNGR1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IFNGR1 Rabbit Polyclonal antibody. Positive IP detected in HepG2 cells. Positive WB detected in HepG2 cells. Positive IHC detected in human pancreas cancer tissue. Positive FC detected in HepG2 cells. Observed molecular weight by Western-blot: 90 kDa
Tested applications :
ELISA, WB, IHC, IP, FC
Species reactivity :
Human; other species not tested.
Alternative names :
CD119 antibody; CDw119 antibody; FLJ45734 antibody; IFN gamma R1 antibody; IFN gamma receptor 1 antibody; IFNGR antibody; IFNGR1 antibody; interferon gamma receptor 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IFNGR1 recombinant protein (Accession Number: NM_000416). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 (CD119) and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit. Two subunits bind one IFN-γ dimer. Defects in IFNGR1 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)
References :
Rodriguez FJ, Giannini C, Asmann YW. Gene expression profiling of NF-1-associated and sporadic pilocytic astrocytoma identifies aldehyde dehydrogenase 1 family member L1 (ALDH1L1) as an underexpressed candidate biomarker in aggressive subtypes. Journal of neuropathology and experimental neurology. 67(12):1194-204. 2008.
Related websites: https://www.medchemexpress.com/antibodies.html
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