Name :
IFNGR2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IFNGR2 Rabbit Polyclonal antibody. Positive FC detected in HeLa cells. Positive WB detected in A549 cells, HeLa cells, HepG2 cells. Observed molecular weight by Western-blot: 55 kDa
Tested applications :
ELISA, WB, FC
Species reactivity :
Human; other species not tested.
Alternative names :
AF 1 antibody; IFGR2 antibody; IFN gamma R2 antibody; IFN gamma receptor 2 antibody; IFNGR2 antibody; IFNGT1 antibody; Interferon gamma receptor 2 antibody; Interferon gamma transducer 1 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IFNGR2 recombinant protein (Accession Number: NM_005534). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000
Background :
Interferon-gamam (IFN-γ) is a cytokine critical for innate and adaptive immunity against viral and intracellular bacterial infections and for tumor control. Cellular responses to IFN-γ are activated through its interaction with a heterodimeric receptor consisting of two subunits, IFNGR1 and IFNGR2. IFNGR1 is the ligand-binding subunit which binds IFN-γ with high affinity, whereas IFNGR2 serves as the accessory subunit which attaches to IFN-γ with a significantly lower affinity. Two subunits bind one IFN-γ dimer. Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection. (PMID: 17981204; 946248; 10888113)
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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