Name :
IGF2BP3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IGF2BP3 Rabbit Polyclonal antibody. Positive IF detected in MCF-7 cells. Positive IHC detected in human pancreas cancer tissue. Positive WB detected in HepG2 cells, BxPC-3 cells, HeLa cells, mouse brain tissue. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 64 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
DKFZp686F1078 antibody; hKOC antibody; IGF II mRNA binding protein 3 antibody; IGF2 mRNA binding protein 3 antibody; IGF2BP3 antibody; IMP 3 antibody; IMP3 antibody; KOC1 antibody; VICKZ family member 3 antibody; VICKZ3 antibody
Immunogen :
Human IGF2BP3 Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IGF2BP3 recombinant protein (Accession Number: NM_006547). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
IGF2BP3, also named as IMP3, Koc1 and VICKZ3, belongs to the RRM IMP/VICKZ family. It is one of the RNA binding proteins involved in mRNA localization and translational control. IGF2BP3 is expressed during embryogenesis, as well as in some malignant tumors. It can be used as an independent prognostic factor for osteosarcoma. Both isoforms (64kd and 22kd) of IGFBP3 can be recognized by this antibody. And IGFBP3 is nuclear and cytoplasm stains.
References :
Li W, Liu D, Chang W. Role of IGF2BP3 in trophoblast cell invasion and migration. Cell death & disease. 5:e1025. 2014. Nguyen LH, Robinton DA, Seligson MT. Lin28b is sufficient to drive liver cancer and necessary for its maintenance in murine models. Cancer cell. 26(2):248-61. 2014. Wang Y, Yue D, Xiao M. C1QBP negatively regulates the activation of oncoprotein YBX1 in the renal cell carcinoma as revealed by interactomics analysis. Journal of proteome research. 14(2):804-13. 2015. Shantha Kumara H, Kirchoff D, Caballero OL. Expression of the cancer testis antigen IGF2BP3 in colorectal cancers; IGF2BP3 holds promise as a specific immunotherapy target. Oncoscience. 2(6):607-14. 2015. Chen P, Wang SJ, Wang HB. The distribution of IGF2 and IMP3 in osteosarcoma and its relationship with angiogenesis. Journal of molecular histology. 43(1):63-70. 2012. Reschke M, Clohessy JG, Seitzer N. Characterization and analysis of the composition and dynamics of the mammalian riboproteome. Cell reports. 4(6):1276-87. 2013.
Related websites: https://www.medchemexpress.com/antibodies.html
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