Name :
IL1 beta antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IL1 beta Rabbit Polyclonal antibody. Positive WB detected in A431 cells, human adrenal gland tissue, RAW 264.7 cells, Transfected HEK-293 cells. Positive IF detected in HeLa cells. Positive IHC detected in human skin tissue, human heart tissue, human lung tissue, human ovary tissue, human placenta tissue, human testis tissue, mouse heart tissue. Observed molecular weight by Western-blot: 30-35 kDa
Tested applications :
ELISA, IHC, IF, WB
Species reactivity :
Human, Mouse; other species not tested.
Alternative names :
IL1 beta antibody; Catabolin antibody; IL 1 antibody; IL 1 beta antibody; IL1 BETA antibody; IL1B antibody; IL1beta antibody; IL1F2 antibody; IL-1β antibody; Interleukin 1 beta antibody; interleukin 1 antibody; beta antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IL1 beta recombinant protein (Accession Number: NM_000576). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:20-1:200IF: 1:20-1:200
Background :
Interleukin-1, produced mainly by blood monocytes, mediates the panoply of host reactions collectively known as acute phase response. It is identical to endogenous pyrogen. The multiple biologic activities that define IL1 are properties of a 15- to 18-kD protein that is derived from a 30- to 35-kD precursor. Interleukin 1β (IL-1B) is a member of the interleukin 1 cytokine family. It is a pro-inflammatory cytokine against infection, playing an important role in the pathogenesis of cancers. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets. The expression level of IL-1B is very low.
References :
Xue H, Zhang XY, Liu JM, Song Y, Liu TT, Chen D. NDGA reduces secondary damage after spinal cord injury in rats via anti-inflammatory effects. Brain research. 1516:83-92. 2013. Wang CP, Zhang LZ, Li GC. Mulberroside A protects against ischemic impairment in primary culture of rat cortical neurons after oxygen-glucose deprivation followed by reperfusion. Journal of neuroscience research. 92(7):944-54. 2014. Zhang RN, Zheng B, Li LM, Zhang J, Zhang XH, Wen JK. Tongxinluo inhibits vascular inflammation and neointimal hyperplasia through blockade of the positive feedback loop between miR-155 and TNF-α. American journal of physiology. Heart and circulatory physiology. 307(4):H552-62. 2014. Yan Y, Jiang W, Spinetti T. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 38(6):1154-63. 2013. Xu D, Hu L, Su C. Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin. Toxicology and applied pharmacology. 280(2):305-13. 2014. Wu X, He L, Chen F. Impaired autophagy contributes to adverse cardiac remodeling in acute myocardial infarction. PloS one. 9(11):e112891. 2014. Owusu L, Wang B, Du Y, Li W, Xin Y. The quantum of initial transformed cells potentially modulates the type of local inflammation mechanism elicited by surrounding normal epithelial tissues and systemic immune pattern for tumor arrest or progression. Journal of Cancer. 6(2):128-38. 2015. Peng K, Liu L, Wei D. P2X7R is involved in the progression of atherosclerosis by promoting NLRP3 inflammasome activation. International journal of molecular medicine. 35(5):1179-88. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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