Name :
IL13RA2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
IL13RA2 Rabbit Polyclonal antibody. Positive IHC detected in human breast cancer tissue, human brain tissue, human gliomas tissue, human ovary tumor tissue. Positive WB detected in rat thymus tissue, HeLa cells, rat liver tissue. Observed molecular weight by Western-blot: 65 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
CD213A2 antibody; CT19 antibody; IL 13 receptor subunit alpha 2 antibody; IL 13R antibody; IL 13R alpha 2 antibody; IL 13R subunit alpha 2 antibody; IL 13RA2 antibody; IL13BP antibody; IL13R antibody; IL13RA2 antibody; IL13Ralpha2 antibody; Interleukin 13 binding protein antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of IL13RA2 recombinant protein (Accession Number: NM_000640). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:50-1:500
Background :
IL13RA2, also named as IL13R and CD213a2, belongs to the type I cytokine receptor family. It binds as a monomer with high affinity to interleukin-13 (IL13), but not to interleukin-4 (IL4). IL13RA2 lacks the cytoplasmic domain for signaling, indicating that it acts as a decoy receptor. IL13RA2 gene polymorphisms have been associated with systemic sclerosis (PMID: 16981293). Overexpression of IL13RA2 gene has been reported in several types of cancer, including melanoma, lung cancer, and brain tumor, which makes it a potential immunotherapeutic target (PMID: 19895199; 24970476; 24021875).
References :
Akiyama Y, Komiyama M, Miyata H. Novel cancer-testis antigen expression on glioma cell lines derived from high-grade glioma patients. Oncology reports. 31(4):1683-90. 2014. Brøchner CB, Holst CB, Møllgård K. Outer brain barriers in rat and human development. Frontiers in neuroscience. 9:75. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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