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Name :
IL2 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
IL2 Mouse Monoclonal antibody. Positive WB detected in Jurkat cells. Positive IHC detected in human tonsillitis tissue, human breast cancer tissue. Observed molecular weight by Western-blot: 18 kDa

Tested applications :
ELISA, WB, IHC

Species reactivity :
Human; other species not tested.

Alternative names :
Aldesleukin antibody; IL 2 antibody; IL2 antibody; interleukin 2 antibody; lymphokine antibody; T cell growth factor antibody; TCGF antibody

Immunogen :
Human IL2 Recombinant protein (His tag)

Isotype :
Mouse IgG2a

Preparation :
This antibody was obtained by immunization of IL2 recombinant protein (Accession Number: NM_000586). Purification method: Protein A purified.

Clonality :
Monoclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200

Background :
IL2 is a secreted cytokine involved in the operation and regulation of immune system. IL2 plays a pivotal role in T-cell activation and effector functions, including T cell proliferation, interferon-γproduction and cytotoxicity. IL2 can stimulate the propagation of lymphocytes and induce the cytotoxic T lymphocytes and lymphokine-activated killer cells for tumor cells. IL2 also influences memory T cell homeostasis through the regulation of memory T cell numbers and enhances major histocompatibility complex II (MHC II) expression on tumor cells.

References :
Wang C, Chen K, Xia Y. N-acetylcysteine attenuates ischemia-reperfusion-induced apoptosis and autophagy in mouse liver via regulation of the ROS/JNK/Bcl-2 pathway. PloS one. 9(9):e108855. 2014.

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel