Name :
ING4 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to ING4
Tested applications :
WB, IHC
Species reactivity :
Human
Alternative names :
ING4 antibody; my036 antibody; p29ING4 antibody; inhibitor of growth protein 4 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide of human ING4
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, pH7.3.
Storage instructions :
Store at 4℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:1000IHC 1:20 – 1:50
Background :
Component of the HBO1 complex which has a histone H4-specific acetyltransferase activity, a reduced activity toward histone H3 and is responsible for the bulk of histone H4 acetylation in vivo. Through chromatin acetylation it may function in DNA replication. May inhibit tumor progression by modulating the transcriptional output of signaling pathways which regulate cell proliferation. Can suppress brain tumor angiogenesis through transcriptional repression of RELA/NFKB3 target genes when complexed with RELA. May also specifically suppress loss of contact inhibition elicited by activated oncogenes such as MYC. Represses hypoxia inducible factor’s (HIF) activity by interacting with HIF prolyl hydroxylase 2 (EGLN1). Can enhance apoptosis induced by serum starvation in mammary epithelial cell line HC11 (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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