Name :
Anti-BPHL antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Rabbit polyclonal to BPHL
Tested applications :
ELISA, WB, IHC-P, IP
Species reactivity :
Human BPHL
Alternative names :
MCNAA antibody; BPH-RP antibody; VACVASE antibody; AI115341 antibody; 2010012D11Rik antibody; 5730533B08Rik antibody; 2010012D11Rik antibody; 5730533B08Rik antibody; AI115341 antibody; biphenyl hydrolase-like (serine hydrolase antibody; biphenyl hydrolase-like (serine hydrolase) antibody; biphenyl hydrolase-like protein antibody; biphenyl hydrolase-like protein antibody; biphenyl hydrolase-related protein antibody; Bphl antibody; BPHL antibody; BPH-RP antibody; breast epithelial mucin-associated antigen antibody; breast epithelial mucin-associated antigen) antibody; MCNAA antibody; VACVase antibody; VACVASE antibody; valacyclovir hydrolase antibody; valacyclovir hydrolase antibody; valacyclovirase antibody; valacyclovirase antibody
Immunogen :
Human BPHL (His Tag) recombinant protein
Isotype :
Rabbit IgG
Preparation :
Produced in rabbits immunized with purified, recombinant Human BPHL (rh BPHL; Q86WA6-1; Ser38-Gln291). BPHL specific IgG was purified by Human BPHL affinity chromatography.
Clonality :
Polyclonal
Formulation :
0.2 μm filtered solution in PBS
Storage instructions :
This antibody can be stored at 2℃-8℃ for one month without detectable loss of activity. Antibody products are stable for twelve months from date of receipt when stored at -20℃ to -80℃. Preservative-Free.Sodium azide is recommended to avoid contamination (final concentration 0.05%-0.1%). It is toxic to cells and should be disposed of properly. Avoid repeated freeze-thaw cycles.
Applications :
WB: 5-10 μg/mlELISA:0.1-0.2 μg/mLThis antibody can be used at 0.1-0.2 μg/mL with the appropriate secondary reagents to detect Human BPHL. The detection limit for Human BPHL is IHC-P: 0.1-2 μg/mlIP: 1-4 μg/mg of lysate
Background :
BPHL is a member of the serine protease family. BPHL is expressed large quantities in liver and kidney and in minor quantities in heart, intestine and skeletal muscle. BPHL is a specific alpha-amino acid ester hydrolase that prefers small, hydrophobic, and aromatic side chains and does not have a stringent requirement for the leaving group other than preferring a primary alcohol. It catalyzes the hydrolytic activation of amino acid ester prodrugs of nucleoside analogs such as valacyclovir and valganciclovir. BPHL also activates valacyclovir to acyclovir. It may play a role in detoxification processes.
References :
Lai L. et al., 2008, J Biol Chem. 283 (14): 9318-27. Davila S. et al., 2010, Genes Immun. 11 (3): 232-8. Hendrickson SL. et al., 2010, PLoS One. 5 (9): e12862.
Related websites: https://www.medchemexpress.com/antibodies.html
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