Name :
iNOS antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
iNOS Rabbit Polyclonal antibody. Positive IHC detected in human liver tissue. Positive IF detected in HeLa cells.
Tested applications :
ELISA, IHC, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
HEP NOS antibody; HepatOCyte NOS antibody; Inducible NO synthase antibody; Inducible NOS antibody; INOS antibody; NOS antibody; NOS type II antibody; NOS2 antibody; NOS2A antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_000625). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200IF: 1:20-1:200
Background :
NOS2, also named as iNOS and NOS2A, produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. In macrophages, NO mediates tumoricidal and bactericidal actions. NO is a reactive free radical which acts as a biologic mediator in several processes, including neurotransmission and antimicrobial and antitumoral activities. NOS2 is a nitric oxide synthase which is expressed in liver and is inducible by a combination of lipopolysaccharide and certain cytokines. This antibody is specific to NOS2.
References :
Zhang S, Lu B, Han X. Protection of the flavonoid fraction from Rosa laevigata Michx fruit against carbon tetrachloride-induced acute liver injury in mice. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 55:60-9. 2013. Zhang S, Qi Y, Xu Y. Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. Neurochemistry international. 63(5):522-32. 2013. Xu D, Hu L, Su C. Tetrachloro-p-benzoquinone induces hepatic oxidative damage and inflammatory response, but not apoptosis in mouse: the prevention of curcumin. Toxicology and applied pharmacology. 280(2):305-13. 2014. Dong D, Yin L, Qi Y, Xu L, Peng J. Protective Effect of the Total Saponins from Rosa laevigata Michx Fruit against Carbon Tetrachloride-Induced Liver Fibrosis in Rats. Nutrients. 7(6):4829-50. 2015. Liu S, Wang ZH, Xu B, Chen K, Sun JY, Ren LP. SENP1 inhibits the IH-induced apoptosis and nitric oxide production in BV2 microglial cells. Biochemical and biophysical research communications. 467(4):651-6. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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