Name :
INSIG2 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
INSIG2 Rabbit Polyclonal antibody. Positive IP detected in mouse liver tissue. Positive WB detected in rat liver tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human liver tissue. Observed molecular weight by Western-blot: 30 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human, Mouse, Rat; other species not tested.
Alternative names :
INSIG 2 antibody; INSIG2 antibody; insulin induced gene 2 antibody; Insulin induced gene 2 protein antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of INSIG2 recombinant protein (Accession Number: XM_047444640). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200IF: 1:10-1:100
Background :
INSIG2, also named as insulin induced gene 2, mediates feedback control of cholesterol synthesis by controlling SCAP and HMGCR. INSIG2 may bring HMGCR into ubiquitin-mediated proteasomal degradation. Insig2 protein are endoplasmic reticulum proteins that block the processing of sterol regulatory element binding proteins (SREBPs) by binding to SREBP cleavage-activating protein (SCAP), and thus prevent SCAP from escorting SREBPs to the Golgi. INSIG-2 may play an important role in therapy of hypercholesterolemia.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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