Name :
Integrin alpha-4 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Integrin alpha-4 Rabbit Polyclonal antibody. Positive IHC detected in human tonsillitis tissue. Positive WB detected in Jurkat cells. Observed molecular weight by Western-blot: 115 kDa
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
CD49D antibody; IA4 antibody; Integrin alpha 4 antibody; Integrin alpha IV antibody; ITGA4 antibody; VLA 4 subunit alpha antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Peptide (Accession Number: NM_000885). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IHC: 1:20-1:200
Background :
ITGA4, also named as CD49D, belongs to the integrin alpha chain family. ITGA4 is a receptor for fibronectin, VCAM1 and MADCAM1. ITGA4 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. It recognizes the sequence Q-I-D-S in VCAM1. I It recognizes the sequence L-D-T in MADCAM1. On activated endothelial cells ITGA4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines. It may also participate in cytolytic T-cell interactions with target cells.
References :
Zhao XP, Wang M, Song Y. Membrane microvesicles as mediators for melanoma-fibroblasts communication: roles of the VCAM-1/VLA-4 axis and the ERK1/2 signal pathway. Cancer letters. 360(2):125-33. 2015.
Related websites: https://www.medchemexpress.com/antibodies.html
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