Name :
Integrin beta-7 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Integrin beta-7 Rabbit Polyclonal antibody. Positive WB detected in K-562 cells, human lung tissue. Positive IHC detected in human lymphoma. Observed molecular weight by Western-blot: 87kd
Tested applications :
ELISA, WB, IHC
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ITGB7 antibody; Integrin beta 7 antibody; integrin antibody; beta 7 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Integrin beta-7 recombinant protein (Accession Number: XM_005268851). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IHC: 1:20-1:200
Background :
ITGB7 (integrin, beta7) is a single-pass type I membrane protein that belongs to the integrin beta chain family. The integrins are a large family of cell-surface glycoprotein receptors that play key roles in leucocyte adhesion, signalling, proliferation and migration by binding as heterodimers to specific ligands. The beta7 integrin associates with alpha4 integrin to form a heterodimer, alpha4/beta7, which interacts with MADCAM1, VCAM, fibronectin, and may also interact with HIV-1 gp120. The beta7 integrin can also form a heterodimer with alphaE integrin, and the dimer, alphaE/beta7 integrin, is a receptor for E-cadherin. ITGB7 is expressed in a variety of leukocyte lines.
References :
Sundqvist J, Andersson KL, Scarselli G, Gemzell-Danielsson K, Lalitkumar PG. Expression of adhesion, attachment and invasion markers in eutopic and ectopic endometrium: a link to the aetiology of endometriosis. Human reproduction (Oxford, England). 27(9):2737-46. 2012. Halpert G, Eitan T, Voronov E. Multifunctional activity of a small tellurium redox immunomodulator compound, AS101, on dextran sodium sulfate-induced murine colitis. The Journal of biological chemistry. 289(24):17215-27. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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