Name :
INVS antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
INVS Rabbit Polyclonal antibody. Positive WB detected in MCF7 cells, HepG2 cells, Jurkat cells, K-562 cells, L02 cells, mouse skeletal muscle tissue, Raji cells, SH-SY5Y cells. Positive IHC detected in human breast cancer tissue, human hepat℃irrhosis tissue. Positive IF detected in Hela cells, hTERT-RPE1 cells. Observed molecular weight by Western-blot: 110-115 kDa
Tested applications :
ELISA, WB, IHC, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
INV antibody; inversin antibody; INVS antibody; KIAA0573 antibody; NephrOCystin 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of INVS recombinant protein (Accession Number: BC006370). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:1000IHC: 1:20-1:200IF: 1:10-1:100
Background :
INVS, short for inversin, plays a role in primary cilia function and involvement in the cell cycle. It is required for normal renal development and establishment of left-right axis. INVS may involve in Wnt signaling pathways by acting as a molecular switch between different them. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling. This antibody is a rabbit polyclonal antibody raised against part of N-terminus of human INVS.
References :
Leh S, Hultström M, Rosenberger C, Iversen BM. Afferent arteriolopathy and glomerular collapse but not segmental sclerosis induce tubular atrophy in old spontaneously hypertensive rats. Virchows Archiv : an international journal of pathology. 459(1):99-108. 2011. Oud MM, van Bon BW, Bongers EM. Early presentation of cystic kidneys in a family with a homozygous INVS mutation. American journal of medical genetics. Part A. 164A(7):1627-34. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
BRD4 Antibody
Cyclin B1 Antibody
c-Jun Antibody: c-Jun Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 36 kDa, targeting to c-Jun. It can be used for WB,ICC,IHC-P,IP assays with tag free, in the background of Human, Mouse, Rat.
