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Name :
Islet 1 antibody

Documents :
DataSheet Material Safety Data Sheets (MSDS)

Description :
Islet 1 Rabbit Polyclonal antibody. Positive IHC detected in human pancreas cancer tissue, human pancreas tissue. Positive WB detected in BxPC-3 cells, HeLa cells. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 39kd, 45kd

Tested applications :
ELISA, WB, IP, IHC

Species reactivity :
Human,Mouse,Rat; other species not tested.

Alternative names :
Isl 1 antibody; ISL LIM homeobox 1 antibody; ISL1 antibody; Islet 1 antibody; ISLET1 antibody

Immunogen :

Isotype :
Rabbit IgG

Preparation :
This antibody was obtained by immunization of Islet 1 recombinant protein (Accession Number: NM_002202). Purification method: Antigen affinity purified.

Clonality :
Polyclonal

Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.

Storage instructions :
Store at -20℃. DO NOT ALIQUOT

Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200

Background :
ISL1 belongs to the LIM homeodomain transcription factor family that binds to the enhancer region of the insulin gene. It plays a pivotal role in cardiogenesis, and lacking ISL1 expression results in growth arrest or displays profound defects in heart development, including atria, ventricle, and the inflow and outflow tracts.

References :

Antibodies are immunoglobulins secreted by effector lymphoid B cells into the bloodstream. Antibodies consist of two light peptide chains and two heavy peptide chains that are linked to each other by disulfide bonds to form a “Y” shaped structure. Both tips of the “Y” structure contain binding sites for a specific antigen. Antibodies are commonly used in medical research, pharmacological research, laboratory research, and health and epidemiological research. They play an important role in hot research areas such as targeted drug development, in vitro diagnostic assays, characterization of signaling pathways, detection of protein expression levels, and identification of candidate biomarkers.
Related websites: https://www.medchemexpress.com/antibodies.html
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Author: Gardos- Channel