Name :
ITM2C antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ITM2C Mouse Monoclonal antibody. Positive IF detected in HepG2 cells. Positive WB detected in A431 cells. Observed molecular weight by Western-blot: 35kd
Tested applications :
ELISA, WB, IF
Species reactivity :
Human; other species not tested.
Alternative names :
BRICD2C antibody; Cerebral protein 14 antibody; E25 antibody; E25C antibody; integral membrane protein 2C antibody; ITM2C antibody; ITM3 antibody; PSEC0047 antibody; Transmembrane protein BRI3 antibody
Immunogen :
Isotype :
Mouse IgG2a
Preparation :
This antibody was obtained by immunization of ITM2C recombinant protein (Accession Number: NM_001012516). Purification method: Caprylic acid/ammonium sulfate precipitation.
Clonality :
Monoclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000IF: 1:20-1:200
Background :
The Integral membrane protein 2C (ITM2C) is a type II integral transmembrane protein belonging to a family composed of at least two other members, ITM2A and ITM2B. ITM2C, often called transmembrane protein BRI3, is highly expressed in brain tissue. Yeast two-hybrid screen system revealed that BRI3 could interact with beta-secretase beta-amyloid protein converting enzyme (BACE)1 and the microtubule-destabilizing protein SCG10 (STMN2). It may play a role in TNF-induced cell death and neuronal differentiation. BRI3 was found to inhibit the various processing of amyloid precursor protein (APP) by blocking the access of alpha- and beta-secretases to APP, competitive inhibition of APP processing by BRI3 may provide a new approach to Alzheimer disease (AD) therapy and prevention.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Oct-4 Antibody
Rilotumumab
N Cadherin Antibody: N Cadherin Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 100 kDa, targeting to N Cadherin. It can be used for WB,IP assays with tag free, in the background of Human, Mouse, Rat.
