Name :
ITPKA antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
ITPKA Rabbit Polyclonal antibody. Positive IP detected in mouse brain tissue. Positive WB detected in mouse brain tissue. Positive IF detected in HepG2 cells. Positive IHC detected in human gliomas tissue. Observed molecular weight by Western-blot: 51 kDa
Tested applications :
ELISA, WB, IHC, IF, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
InsP 3 kinase A antibody; IP3 3 kinase A antibody; IP3K A antibody; IP3KA antibody; ITPKA antibody
Immunogen :
Human ITPKA Recombinant protein (GST tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of ITPKA recombinant protein (Accession Number: NM_002220). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:1000IHC: 1:20-1:200IF: 1:20-1:200
Background :
ITPKA(Inositol-trisphosphate 3-kinase A) belongs to the inositol phosphokinase (IPK) family. It accumulates in dendritic spines and seems to be critically involved in synaptic plasticity. The protein possesses two functional activities. In neurons, ITPKA is targeted to F-actin via an N-terminal actin binding domain (amino acids 1–66) and is relevant for long term potentiation and spatial learning(PMID:20022963).
References :
Windhorst S, Kalinina T, Schmid K. Functional role of inositol-1,4,5-trisphosphate-3-kinase-A for motility of malignant transformed cells. International journal of cancer. 129(6):1300-9. 2011. Ashour DJ, Pelka B, Jaaks P. The catalytic domain of inositol-1,4,5-trisphosphate 3-kinase-a contributes to ITPKA-induced modulation of F-actin. Cytoskeleton (Hoboken, N.J.). 72(2):93-100. 2015. Li J, Zhu YH, Huang P, Zhang B, Sun J, Guan XY. ITPKA expression is a novel prognostic factor in hepatocellular carcinoma. Diagnostic pathology. 10:136. 2015. there was a problem with your PMID, try again.
Related websites: https://www.medchemexpress.com/antibodies.html
Popular product recommendations:
Glutathione peroxidase 1 Antibody (YA750)
Anetumab
Proteasome 20S LMP7 Antibody: Proteasome 20S LMP7 Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 30 kDa, targeting to Proteasome 20S LMP7. It can be used for WB,ICC,IF,IHC-P,FC assays with tag free, in the background of Human, Mouse, Rat.
