Name :
Kallikrein 5 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Kallikrein 5 Rabbit Polyclonal antibody. Positive IHC detected in human skin tissue.
Tested applications :
ELISA, IHC
Species reactivity :
Human; other species not tested.
Alternative names :
Kallikrein 5 antibody; Kallikrein like protein 2 antibody; kallikrein related peptidase 5 antibody; KLK L2 antibody; KLK5 antibody; KLKL2 antibody; SCTE antibody; Stratum corneum tryptic enzyme antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of Kallikrein 5 recombinant protein (Accession Number: NM_001077491). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.1% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: IHC: 1:20-1:200
Background :
KLK5(Kallikrein-5) is also named as SCTE and belongs to the kallikrein subfamily. This protein is predicted to be a secreted serine protease, and the enzyme is found to have proteolytic activity. In serum and ascites fluid, the protein is present in two forms, one at a relatively lower molecular mass (around 50 kDa), and another one around 150-180 kDa and native KLK5 is highly glycosylated or that it may interact with the gel filtration column, leading to delayed retention(PMID:12873991). The activation of the enzyme has been shown to require cleavage of an arginine residue (Arg66-Ile67), suggesting that a trypsin-like serine protease may be involved in this process(PMID:15713679).
References :
Nin M, Katoh N, Kokura S, Handa O, Yoshikawa T, Kishimoto S. Dichotomous effect of ultraviolet B on the expression of corneodesmosomal enzymes in human epidermal keratinocytes. Journal of dermatological science. 54(1):17-24. 2009.
Related websites: https://www.medchemexpress.com/antibodies.html
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