Name :
KANK2 Polyclonal Antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
Polyclonal antibody to KANK2
Tested applications :
WB
Species reactivity :
Human, Mouse
Alternative names :
KANK2 antibody; ANKRD25 antibody; MXRA3 antibody; PPKWH antibody; SIP antibody; KN motif and ankyrin repeat domains 2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
Antigen: A synthetic peptide of human KANK2
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide, pH7.3.
Storage instructions :
Store at 4℃. Avoid freeze / thaw cycles.
Applications :
WB 1:500 – 1:2000
Background :
Involved in transcription regulation by sequestering in the cytoplasm nuclear receptor coactivators such as NCOA1, NCOA2 and NCOA3. Involved in regulation of caspase-independent apoptosis by sequestering the proapoptotic factor AIFM1 in mitochondria. Pro-apoptotic stimuli can induce its proteasomal degradation allowing the translocation of AIFM1 to the nucleus to induce apoptosis. Involved in the negative control of vitamin D receptor signaling pathway. Involved in actin stress fibers formation through its interaction with ARHGDIA and the regulation of the Rho signaling pathway. May thereby play a role in cell adhesion and migration, regulating for instance podocytes migration during development of the kidney. Through the Rho signaling pathway may also regulate cell proliferation (By similarity).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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