Name :
KAP1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KAP1 Rabbit Polyclonal antibody. Positive IHC detected in human colon cancer tissue. Positive IF detected in Hela cells. Positive FC detected in HeLa cells. Positive IP detected in HeLa cells. Positive WB detected in HeLa cells, mouse testis tissue, rat spleen tissue. Observed molecular weight by Western-blot: 100kd
Tested applications :
ELISA, WB, IHC, IF, FC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
FLJ29029 antibody; KAP 1 antibody; KAP1 antibody; KRAB assOCiated protein 1 antibody; KRAB interacting protein 1 antibody; KRIP 1 antibody; Nuclear corepressor KAP 1 antibody; RING finger protein 96 antibody; RNF96 antibody; TF1B antibody; TIF1 beta antibody; TIF1B antibody; TRIM28 antibody; tripartite motif containing 28 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KAP1 recombinant protein (Accession Number: NM_005762). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:1000-1:10000IP: 1:500-1:5000IHC: 1:20-1:200IF: 1:10-1:100
Background :
KAP1, also named as TRIM28 or RNF96, is a 835 amino acid protein, which contain one RING-type zinc finger, one PHD-type zinc finger, one bromo domain and two B box-type zinc fingers. KAP1 localizes in the nucleus and Belongs to the TRIM/RBCC family. KAP1 is a nuclear corepressor for KRAB domain-containing zinc finger proteins and mediates gene silencing by recruiting CHD3, a subunit of the nucleosome remodeling and deacetylation (NuRD) complex, and SETDB1 to the promoter regions of KRAB target genes. KAP1 is expressed in all tissues tested including spleen, thymus, prostate, testis, ovary, small intestine, colon and peripheral blood leukocytes.
References :
Liu L, Zhao E, Li C. TRIM28, a new molecular marker predicting metastasis and survival in early-stage non-small cell lung cancer. Cancer epidemiology. 37(1):71-8. 2013. Bojkowska K, Aloisio F, Cassano M. Liver-specific ablation of Krüppel-associated box-associated protein 1 in mice leads to male-predominant hepatosteatosis and development of liver adenoma. Hepatology (Baltimore, Md.). 56(4):1279-90. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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