Name :
KATNB1 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KATNB1 Rabbit Polyclonal antibody. Positive IF detected in HeLa cells. Positive WB detected in HeLa cells, A431 cells, HepG2 cells, mouse skeletal muscle tissue. Positive IP detected in HeLa cells. Observed molecular weight by Western-blot: 72-80 kDa
Tested applications :
ELISA, WB, IP, IF
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
KAT antibody; Katanin p80 subunit B1 antibody; KATNB1 antibody; p80 katanin antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KATNB1 recombinant protein (Accession Number: NM_005886). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IF: 1:50-1:500
Background :
Katanin p80 WD40-containing subunit B1 is a protein that in humans is encoded by the KATNB1 gene. Microtubules, polymers of alpha and beta tubulin subunits, form the mitotic spindle of a dividing cell and help to organize membranous organelles during interphase. Katanin is a heterodimer that consists of a 60 kDa ATPase (p60 subunit A 1) and an 80 kDa accessory protein (p80 subunit B 1). The p60 subunit acts to sever and disassemble microtubules, while the p80 subunit targets the enzyme to the centrosome. Katanin is a member of the AAA family of ATPases.
References :
Jiang K, Hua S, Mohan R. Microtubule minus-end stabilization by polymerization-driven CAMSAP deposition. Developmental cell. 28(3):295-309. 2014. Hu WF, Pomp O, Ben-Omran T. Katanin p80 regulates human cortical development by limiting centriole and cilia number. Neuron. 84(6):1240-57. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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