Name :
KCNJ15 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KCNJ15 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HepG2 cells. Positive IP detected in HepG2 cells. Positive IHC detected in human liver tissue. Observed molecular weight by Western-blot: 35 kDa
Tested applications :
ELISA, WB, IHC, IP
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
IRKK antibody; KCNJ14 antibody; KCNJ15 antibody; KIR1.3 antibody; KIR4.2 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KCNJ15 recombinant protein (Accession Number: XM_011529560). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000IP: 1:200-1:2000IHC: 1:20-1:200
Background :
KCNJ15, also named as KIR1.3, KIR4.2, and IRKK, is a multi-pass membrane protein belonging to the inwardly-rectifying potassium channel (KIR) family. KIR channels perform functions as diverse as the regulation of resting membrane potential, maintenance of potassium ions homeostasis, control of heart rate and hormone secretion. Cloned from human kidney, the KCNJ15 gene is localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1) and has been identified as a type 2 diabetes-associated risk gene. The gene is most readily expressed in the pancreas and kidney and less in the lung. (PMID: 8995301; 9299242; 20085713)
References :
Nakajima K, Zhu K, Sun YH. KCNJ15/Kir4.2 couples with polyamines to sense weak extracellular electric fields in galvanotaxis. Nature communications. 6:8532. 2015. Kobayashi A, Donaldson DS, Kanaya T. Identification of novel genes selectively expressed in the follicle-associated epithelium from the meta-analysis of transcriptomics data from multiple mouse cell and tissue populations. DNA research : an international journal for rapid publication of reports on genes and genomes. 19(5):407-22. 2012.
Related websites: https://www.medchemexpress.com/antibodies.html
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