Name :
Anti-c-Kit (7F12) Mouse antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
c-Kit (7F12) Mouse monoclonal antibody
Tested applications :
WB, IHC-P
Species reactivity :
Human
Alternative names :
Immunogen :
Isotype :
Mouse IgG1
Preparation :
Antigen: Purified recombinant fragment of human KIT expressed in E. Coli.
Clonality :
Monoclonal
Formulation :
Ascitic fluid containing 0.03% sodium azide.
Storage instructions :
Store at 4°C short term. Store at -20°C long term. Avoid freeze / thaw cycle.
Applications :
WB: 1/500 – 1/2000IHC: 1/200 – 1/1000ELISA: 1/10000
Background :
Swiss-Prot Acc.P10721.The c-Kit proto-oncogene is a member of the receptor tyrosine kinase family and, more specifically, is closely related to the platelet derived growth factor receptor (PDGFR). c-Kit, the normal cellular homolog of the HZ4-feline sarcoma virus transforming gene (v-Kit), encodes a transmembrane receptor. c-Kit regulates a variety of biological responses including chemotaxis, cell prolif- eration, apoptosis and adhesion. c-Kit is also identical with the product of the W locus in mice and, as such, is integral to the development of mast cells and hematopoiesis. The ligand for the c-Kit receptor (KL) has been identified and is encoded at the murine steel (SI) locus. Kit is the human homolog of the proto- oncogene c-Kit. Mutations in Kit are integral for tumor growth and progression in various cancers.
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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