Name :
KIDINS220 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KIDINS220 Rabbit Polyclonal antibody. Positive WB detected in HeLa cells, HEK-293 cells, human brain tissue, Raji cells. Observed molecular weight by Western-blot: 186-197 kDa
Tested applications :
ELISA, WB
Species reactivity :
Human,Mouse,Rat; other species not tested.
Alternative names :
ARMS antibody; KIAA1250 antibody; KIDINS220 antibody
Immunogen :
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KIDINS220 recombinant protein (Accession Number: NM_001348736). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:500-1:5000
Background :
Kidins220 (Kinase D-interacting substrate 220 kD) is a crucial mediator of signal transduction in neural tissues. Also it named ARMS(Ankyrin Repeat-Rich Membrane Spanning) due to the presence of ankyrin repeats and transmembrane domains together with other binding motifs. It is a multidomain transmembrane protein that not only transduces signaling mediated by the receptor tyrosine kinase (RTK), but also regulates the stability of cytoskeletal network through a number of cytoskeleton-associated proteins, including Septin5, MAPs , and stathmin family members.
References :
Fiala GJ, Janowska I, Prutek F. Kidins220/ARMS binds to the B cell antigen receptor and regulates B cell development and activation. The Journal of experimental medicine. 212(10):1693-708. 2015. Steinberg F, Gallon M, Winfield M. A global analysis of SNX27-retromer assembly and cargo specificity reveals a function in glucose and metal ion transport. Nature cell biology. 15(5):461-71. 2013. Gallon M, Clairfeuille T, Steinberg F. A unique PDZ domain and arrestin-like fold interaction reveals mechanistic details of endocytic recycling by SNX27-retromer. Proceedings of the National Academy of Sciences of the United States of America. 111(35):E3604-13. 2014.
Related websites: https://www.medchemexpress.com/antibodies.html
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