Name :
KIR2DL3 antibody
Documents :
DataSheet Material Safety Data Sheets (MSDS)
Description :
KIR2DL3 Rabbit Polyclonal antibody. Positive WB detected in human liver tissue. Observed molecular weight by Western-blot: 58 kDa
Tested applications :
ELISA, WB
Species reactivity :
human; other species not tested.
Alternative names :
KIR2DL3 antibody; CD158B2 antibody; NKAT2 antibody; MHC class I NK cell receptor antibody; KIR K7c antibody
Immunogen :
Human KIR2DL3 Recombinant protein (His tag)
Isotype :
Rabbit IgG
Preparation :
This antibody was obtained by immunization of KIR2DL3 recombinant protein (Accession Number: NM_015868). Purification method: Antigen affinity purified.
Clonality :
Polyclonal
Formulation :
PBS with 0.02% sodium azide and 50% glycerol pH 7.3.
Storage instructions :
Store at -20℃. DO NOT ALIQUOT
Applications :
Recommended Dilution: WB: 1:200-1:2000
Background :
Killer cell immunoglobulin-like receptors (KIRs) are a diverse family of inhibitory and activating receptors expressed on NK cells and a subset of T cells (PMID: 11861603). These polymorphic receptors interact with specific motifs on HLA class I molecules, modulate NK cytolytic activity and are encoded by genes located on chromosome 19q13.4 (PMID: 17069649). KIR2DL3, also known as CD158B2 or NKAT2, is an inhibitory receptor that is specific for HLA-C alleles (HLA-Cw1, HLA-Cw3 and HLA-Cw7) (PMID: 10196125). It is a 341-amino acid transmembrane glycoprotein consisting of an extracellular region containing two C2-type Ig-like domains, a 19-amino acid hydrophobic transmembrane region, and a long cytoplasmic tail with two immunoreceptor tyrosine-based inhibitory motifs (ITIMs). KIR2DL3 inhibits the cytolytic activity of NK cells thus preventing cell lysis (PMID: 7724594).
References :
Related websites: https://www.medchemexpress.com/antibodies.html
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